Variant position: 142 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 142 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VHASLDKFLASVSTVLTSKY R
Gorilla VHASLDKFLASVSTVLTSKY R
Rhesus macaque VHASLDKFLASVSTVLTSKY R
Chimpanzee VHASLDKFLASVSTVLTSKY R
Mouse VHASLDKFLASVSTVLTSKY R
Rat MHASLDKFLASVSTVLTSKY R
Pig VHASLDKFLANVSTVLTSKY R
Bovine VHASLDKFLANVSTVLTSKY R
Rabbit VHASLDKFLANVSTVLTSKY R
Sheep VHASLDKFLANVSTVLTSKY R
Cat VHASLDKFFSAVSTVLTSKY R
Horse VHASLDKFLSSVSTVLTSKY R
Chicken VHASLDKFLCAVGTVLTAKY R
Xenopus tropicalis THKALDKFLVSVSNVLTSKY R
Zebrafish VHVSVDKFFNNLALALSEKY R
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 142 Hemoglobin subunit alpha
125 – 125 Phosphoserine
132 – 132 Phosphoserine
135 – 135 Phosphothreonine
138 – 138 Phosphothreonine
139 – 139 Phosphoserine
Structural and functional studies of hemoglobin Suresnes (arg 141 alpha 2 replaced by His beta 2). Consequences of disrupting an oxygen-linked anion-binding site.
Poyart C.; Bursaux E.; Arnone A.; Bonaventura J.; Bonaventura C.;
J. Biol. Chem. 255:9465-9473(1980)
Cited for: VARIANT SURESNES HIS-142;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.