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UniProtKB/Swiss-Prot P69905: Variant p.Arg142His

Hemoglobin subunit alpha
Gene: HBA2
Variant information

Variant position:  142
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Arginine (R) to Histidine (H) at position 142 (R142H, p.Arg142His).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from large size and basic (R) to medium size and polar (H)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  0
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  In Suresnes; O(2) affinity up.
Any additional useful information about the variant.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  142
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  142
The length of the canonical sequence.

Location on the sequence:   VHASLDKFLASVSTVLTSKY  R 
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         VHASLDKFLASVSTVLTSKYR

Gorilla                       VHASLDKFLASVSTVLTSKYR

                              VHASLDKFFAAVSTVLTSKYR

Rhesus macaque                VHASLDKFLASVSTVLTSKYR

Chimpanzee                    VHASLDKFLASVSTVLTSKYR

Mouse                         VHASLDKFLASVSTVLTSKYR

Rat                           MHASLDKFLASVSTVLTSKYR

Pig                           VHASLDKFLANVSTVLTSKYR

Bovine                        VHASLDKFLANVSTVLTSKYR

Rabbit                        VHASLDKFLANVSTVLTSKYR

Sheep                         VHASLDKFLANVSTVLTSKYR

Cat                           VHASLDKFFSAVSTVLTSKYR

Horse                         VHASLDKFLSSVSTVLTSKYR

Chicken                       VHASLDKFLCAVGTVLTAKYR

Xenopus tropicalis            THKALDKFLVSVSNVLTSKYR

Zebrafish                     VHVSVDKFFNNLALALSEKYR

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 2 – 142 Hemoglobin subunit alpha
Modified residue 125 – 125 Phosphoserine
Modified residue 132 – 132 Phosphoserine
Modified residue 135 – 135 Phosphothreonine
Modified residue 138 – 138 Phosphothreonine
Modified residue 139 – 139 Phosphoserine


Literature citations

Structural and functional studies of hemoglobin Suresnes (arg 141 alpha 2 replaced by His beta 2). Consequences of disrupting an oxygen-linked anion-binding site.
Poyart C.; Bursaux E.; Arnone A.; Bonaventura J.; Bonaventura C.;
J. Biol. Chem. 255:9465-9473(1980)
Cited for: VARIANT SURESNES HIS-142;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.