Variant position: 356 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 361 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DFCKACWKLQQESRYQTVRS IAAWFT
Chimpanzee DFCKACWKLQQESRYQTMRS IAAWFT
Bovine MFCKACWKLQQEPRYQTVPS IASWFQ
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 361 Galactoside 3(4)-L-fucosyltransferase
35 – 361 Lumenal
Molecular basis for Lewis alpha(1,3/1,4)-fucosyltransferase gene deficiency (FUT3) found in Lewis-negative Indonesian pedigrees.
Mollicone R.; Reguigne I.; Kelly R.J.; Fletcher A.; Watt J.; Chatfield S.; Aziz A.; Cameron H.S.; Weston B.W.; Lowe J.B.; Oriol R.;
J. Biol. Chem. 269:20987-20994(1994)
Cited for: VARIANTS LE(-) ARG-20 AND LYS-356;
Molecular genetic analysis of the human Lewis histo-blood group system.
Nishihara S.; Narimatsu H.; Iwasaki H.; Yazawa S.; Akamatsu S.; Ando T.; Seno T.; Narimatsu I.;
J. Biol. Chem. 269:29271-29278(1994)
Cited for: VARIANT LE(-) LYS-356;
DNA sequencing and screening for point mutations in the human Lewis 'FUT3' gene enables molecular genotyping of the human Lewis blood group system.
Elmgren A.; Boerjeson C.; Svensson L.; Rydberg L.; Larson G.;
Vox Sang. 70:97-103(1996)
Cited for: VARIANTS LE(-) ARG-20; ARG-68; MET-105 AND LYS-356;
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