Variant position: 227 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 394 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human IFETKFQVDKVNFHMFDVGG QRDERRKWIQCFNDVTAIIFV
Mouse IFETKFQVDKVNFHMFDVGG QRDERRKWIQCFNDVTAIIFV
Rat IFETKFQVDKVNFHMFDVGG QRDERRKWIQCFNDVTAIIFV
Bovine IFETKFQVDKVNFHMFDVGG QRDERRKWIQCFNDVTAIIFV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 394 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
39 – 394 G-alpha
223 – 227 GTP
219 – 228 G3 motif
227 – 227 Q -> L. Increases binding to GAS2L2; when associated with N-295.
225 – 227
GTPase inhibiting mutations activate the alpha chain of Gs and stimulate adenylyl cyclase in human pituitary tumours.
Landis C.A.; Masters S.B.; Spada A.; Pace A.M.; Bourne H.R.; Vallar L.;
Cited for: VARIANTS SOMATOTROPHINOMA CYS-201; HIS-201 AND ARG-227;
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