Variant position: 311 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 443 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ERTRYSPIPPSHHQLTLPDP SHHGLHSTPDSPAKPEKNGHA
Chimpanzee ERTRYSPIPPSHHQLTLPDP SHHGLHSTPDSPAKPEKNGHA
Mouse ERTRYSPIPPSHHQLTLPDP SHHGLHSNPDSPAKPEKNGHA
Rat ERTRYSPIPPSHHQLTLPDP SHHGLHSNPDSPAKPEKNGHA
Bovine ERTRYSPIPPSHHQLTLPDP SHHGLHSTPDSPAKPEKNGHA
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 443 D(2) dopamine receptor
214 – 373 Cytoplasmic
211 – 373 Interaction with PPP1R9B
281 – 332 Disordered
A structural polymorphism of human dopamine D2 receptor, D2(Ser311->Cys).
Itokawa M.; Arinami T.; Futamura N.; Hamaguchi H.; Toru M.;
Biochem. Biophys. Res. Commun. 196:1369-1375(1993)
Cited for: VARIANT CYS-311;
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