Variant position: 192 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 350 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GTVACTFNFSPWTNDPKERI NVAVAMLTVRGIIRFIIGFSA
Mouse GKTACTFDFSPWTKDPVEKR KVAVTMLTVRGIIRFIIGFST
Rabbit GKMACTFDWSPWTEDPAEKL KVAISMFMVRGIIRFIIGFST
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 350 fMet-Leu-Phe receptor
163 – 205 Extracellular
Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.
Bao L.; Gerard N.P.; Eddy R.L. Jr.; Shows T.B.; Gerard C.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT LYS-192;
cDNA clones of human proteins involved in signal transduction sequenced by the Guthrie cDNA resource center (www.cdna.org).
Kopatz S.A.; Aronstam R.S.; Sharma S.V.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANTS THR-11 AND LYS-192;
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