Variant position: 276 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 350 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LPYNLVLLADTLMRTQVIQE SCERRNNIGRALDATEILGFL
Gorilla LPYNLVLLADTLMRTQVIQE SCERRNNVSLALDATEILGFL
Rhesus macaque LPYNLVLLADTLMRTHLIKE SCERRNDIGRALDATEILGFL
Chimpanzee LPYNLVLLADTLMRTQVIQE SCERRNNIGRALDATEILGFL
Mouse LPYNLVLLSDTLLGAHLIED TCERRNDIDQALYITEILGFS
Rat LPYNLVLLSDTLLGAHLIQD TCERRNNIDQALYITEILGFS
Rabbit LPYNLVLLADTLMRTHVIQE TCQRRNDIDRALDATEILGFL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 350 C-X-C chemokine receptor type 1
265 – 285 Extracellular
276 – 282
Structure and functional expression of a human interleukin-8 receptor.
Holmes W.E.; Lee J.; Kuang W.-J.; Rice G.C.; Wood W.I.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]; VARIANT THR-276;
Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils.
Liu Y.; Yang S.; Lin A.A.; Cavalli-Sforza L.L.; Su B.;
J. Mol. Evol. 61:691-696(2005)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ARG-31; THR-276 AND CYS-335;
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ARG-31; THR-276; CYS-335 AND LEU-342;
Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3.
Kato H.; Tsuchiya N.; Tokunaga K.;
Genes Immun. 1:330-337(2000)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 223-350; VARIANTS THR-276; THR-306 AND CYS-335;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.