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UniProtKB/Swiss-Prot P25024: Variant p.Ser276Thr

C-X-C chemokine receptor type 1
Gene: CXCR1
Variant information

Variant position:  276
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Polymorphism
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants implicated in disease according to literature reports.
  • Polymorphism: Variants not reported to be implicated in disease.
  • Unclassified: Variants with uncertain implication in disease according to literature reports. Evidence against or in favor of a pathogenic role is limited and/or conflicting.

Residue change:  From Serine (S) to Threonine (T) at position 276 (S276T, p.Ser276Thr).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from small size and polar (S) to medium size and polar (T)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  Common polymorphism.
Any additional useful information about the variant.

Other resources:  
Links to websites of interest for the variant.



Sequence information

Variant position:  276
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  350
The length of the canonical sequence.

Location on the sequence:   LPYNLVLLADTLMRTQVIQE  S CERRNNIGRALDATEILGFL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         LPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFL

Gorilla                       LPYNLVLLADTLMRTQVIQESCERRNNVSLALDATEILGFL

Rhesus macaque                LPYNLVLLADTLMRTHLIKESCERRNDIGRALDATEILGFL

Chimpanzee                    LPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFL

Mouse                         LPYNLVLLSDTLLGAHLIEDTCERRNDIDQALYITEILGFS

Rat                           LPYNLVLLSDTLLGAHLIQDTCERRNNIDQALYITEILGFS

Rabbit                        LPYNLVLLADTLMRTHVIQETCQRRNDIDRALDATEILGFL

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 350 C-X-C chemokine receptor type 1
Topological domain 265 – 285 Extracellular
Helix 276 – 282


Literature citations

Structure and functional expression of a human interleukin-8 receptor.
Holmes W.E.; Lee J.; Kuang W.-J.; Rice G.C.; Wood W.I.;
Science 253:1278-1280(1991)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]; VARIANT THR-276;

Molecular evolution of CXCR1, a G protein-coupled receptor involved in signal transduction of neutrophils.
Liu Y.; Yang S.; Lin A.A.; Cavalli-Sforza L.L.; Su B.;
J. Mol. Evol. 61:691-696(2005)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ARG-31; THR-276 AND CYS-335;

Submission
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ARG-31; THR-276; CYS-335 AND LEU-342;

Single nucleotide polymorphisms in the coding regions of human CXC-chemokine receptors CXCR1, CXCR2 and CXCR3.
Kato H.; Tsuchiya N.; Tokunaga K.;
Genes Immun. 1:330-337(2000)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 223-350; VARIANTS THR-276; THR-306 AND CYS-335;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.