Sequence information
Variant position: 15 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 349 The length of the canonical sequence.
Location on the sequence:
MELAVGNLSEGNAS
W PEPPAPEPGPLFGIGVENFV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MELAVGNLSEGNASW PEPPAPEPGPLFGIGVENFV
Mouse MELAMVNLSEGNGSD PEPPAPESRPLFGIGVENFI
Rat MELAPVNLSEGNGSD PEPPA-EPRPLFGIGVENFI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 349
Galanin receptor type 1
Topological domain
1 – 36
Extracellular
Glycosylation
7 – 7
N-linked (GlcNAc...) asparagine
Glycosylation
12 – 12
N-linked (GlcNAc...) asparagine
Literature citations
Molecular cloning of a functional human galanin receptor.
Habert-Ortoli E.; Amiranoff B.; Loquet I.; Laburthe M.; Mayaux J.-F.;
Proc. Natl. Acad. Sci. U.S.A. 91:9780-9783(1994)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; FUNCTION; VARIANTS CYS-15 AND ASN-334;
Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R).
Lorimer D.D.; Matkowskj K.; Benya R.V.;
Biochem. Biophys. Res. Commun. 241:558-564(1997)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]; VARIANTS CYS-15 AND ASN-334;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.