Variant position: 616 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 699 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human VPLITVTNSKVLLVLFYPIN SCANPFLYAIFTKTFQRDFFL
Mouse VPLITVTNSKVLLVLFYPVN SCANPFLYAVFTKAFQRDFFL
Rat VPLITVTNSKILLVLFYPVN SCANPFLYAIFTKAFQRDFLL
Pig VPLITVTNSKVLLVLFYPVN SCANPFLYAIFTKAFRRDFFL
Bovine VPLITVTNSKVLLVLFYPVN SCANPFLYAIFTKAFQRDFFL
Chicken VPLITVTNSKILLVLFYPVN SCANPFLYAIFTKAFQRDFFL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
27 – 699 Lutropin-choriogonadotropic hormone receptor
606 – 627 Helical; Name=7
Testicular and ovarian resistance to luteinizing hormone caused by inactivating mutations of the luteinizing hormone-receptor gene.
Latronico A.C.; Anasti J.; Arnhold I.J.P.; Rapaport R.; Mendonca B.B.; Bloise W.; Castro M.; Tsigos C.; Chrousos G.P.;
N. Engl. J. Med. 334:507-512(1996)
Cited for: VARIANT LHR TYR-616;
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