Variant position: 37 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 190 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DGEKVDFNTFRGRAVLIENV ASLXGTTTRDFTQLNELQCRF
Mouse DGEKIDFNTFRGRAVLIENV ASLXGTTTRDYNQLNELQCRF
Rat DGEKIDFNTFRGRAVLIENV ASLXGTTTRDYTQLNELQCRF
Caenorhabditis elegans QGEDTPLSNYQGKVLIIVNV ASQCGLTNSNYNQFKELLDVY
Baker's yeast KGESFKFDQLKGKVVLIVNV ASKCGFT-PQYKELEELYKKY
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 190 Glutathione peroxidase 2
40 – 40
40 – 40 Selenocysteine
Structural organization of the human gastrointestinal glutathione peroxidase (GPX2) promoter and 3'-nontranscribed region: transcriptional response to exogenous redox agents.
Kelner M.J.; Bagnell R.D.; Montoya M.A.; Lanham K.A.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANT LEU-37;
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