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UniProtKB/Swiss-Prot P05204: Variant p.Glu7Lys

Non-histone chromosomal protein HMG-17
Gene: HMGN2
Variant information

Variant position:  7
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  US
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Glutamate (E) to Lysine (K) at position 7 (E7K, p.Glu7Lys).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from medium size and acidic (E) to large size and basic (K)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Variant description:  In variant H17.
Any additional useful information about the variant.

Sequence information

Variant position:  7
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  90
The length of the canonical sequence.

Location on the sequence:   MPKRKA  E GDAKGDKAKVKDEPQRRSAR
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         MPKRKAEGDAKGDKAKVKDEPQRRSAR


Mouse                         MPKRKAEGDAKGDKTKVKDEPQRRSAR

Rat                           MPKRNAEGDAKGDKAKVKDEPQRRSAR

Pig                           MPKRKAEGDAKGDKAKVKDEPQRRSAR

Bovine                        MPKRKAEGDAEGDKAKVKDEPQRRSAR

Chicken                       MPKRKAEGDTKGDKAKVKDEPQRRSAR

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

Initiator methionine 1 – 1 Removed
Chain 2 – 90 Non-histone chromosomal protein HMG-17
Region 1 – 90 Disordered
Compositional bias 1 – 26 Basic and acidic residues
Modified residue 25 – 25 Phosphoserine

Literature citations

Comparison of multiple forms of the high mobility group I proteins in rodent and human cells. Identification of the human high mobility group I-C protein.
Giancotti V.; Bandiera A.; Buratti E.; Fusco A.; Marzari R.; Coles B.; Goodwin G.H.;
Eur. J. Biochem. 198:211-216(1991)

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.