Variant position: 322 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 360 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GSPFS--GGPVSFPLAPGPHFG TPGY--GSP--HFTALYSSVPFPEG
Rhesus macaque GSPFS--GGPVSFPLAPGPHFG TPGY--GSP--HFTALYSS
Chimpanzee GSPFS--GGPVSFPLAPGPHFG TPGY--GSP--HFTALYSS
Mouse GTPFP--GGAVSFPLPPGPHFG TPGY--GSP--HFTTLY-S
Pig GSPFP--GGPVSFPLAPGPHFG TPGY--GGP--HFTTLYSS
Bovine GSPFT--GGPVSSPLAPGPHFG TPGY--GGP--HFTTLYSS
Zebrafish PPPPPHMGGTV----LPGQGYP GPAHPGGAPALYMPSLHRP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 360 POU domain, class 5, transcription factor 1
Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues.
Takeda J.; Seino S.; Bell G.I.;
Nucleic Acids Res. 20:4613-4620(1992)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B); VARIANTS ALA-322 AND LEU-357; TISSUE SPECIFICITY;
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