Sequence information
Variant position: 322 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 360 The length of the canonical sequence.
Location on the sequence:
GSPFSGGPVSFPLAPGPHFG
T PGYGSPHFTALYSSVPFPEG
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GSPFS--GGPVSFPLAPGPHFGT PGY--GSP--HFTALYSSVPFPEG
Rhesus macaque GSPFS--GGPVSFPLAPGPHFGT PGY--GSP--HFTALYSS
Chimpanzee GSPFS--GGPVSFPLAPGPHFGT PGY--GSP--HFTALYSS
Mouse GTPFP--GGAVSFPLPPGPHFGT PGY--GSP--HFTTLY-S
Pig GSPFP--GGPVSFPLAPGPHFGT PGY--GGP--HFTTLYSS
Bovine GSPFT--GGPVSSPLAPGPHFGT PGY--GGP--HFTTLYSS
Zebrafish PPPPPHMGGTV----LPGQGYPG PAHPGGAPALYMPSLHRP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 360
POU domain, class 5, transcription factor 1
Literature citations
Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues.
Takeda J.; Seino S.; Bell G.I.;
Nucleic Acids Res. 20:4613-4620(1992)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A AND B); VARIANTS ALA-322 AND LEU-357; TISSUE SPECIFICITY;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.