Variant position: 97 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 330 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GTQTYICNVNHKPSNTKVDK KVEPKSCDKTHTCPPC--PAPEL
Mouse PSETVTCNVAHPASSTKVDK KIVPRDCG----CKPCICTVP
Rat PSQTVTCNVAHPASSTKVDK KIVPRNCGGD--CKPCICTGS
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 330 Immunoglobulin heavy constant gamma 1
6 – 99 Ig-like 1
1 – 98 CH1
103 – 103 Interchain (with light chain)
109 – 109 Interchain (with heavy chain)
112 – 112 Interchain (with heavy chain)
92 – 97
Three-dimensional structure determination of antibodies. Primary structure of crystallized monoclonal immunoglobulin IgG1 KOL, I.
Schmidt W.E.; Jung H.-D.; Palm W.; Hilschmann N.;
Hoppe-Seyler's Z. Physiol. Chem. 364:713-747(1983)
Cited for: PROTEIN SEQUENCE (IMGT ALLELE IGHG1*03); DISULFIDE BONDS; VARIANTS ARG-97; GLU-239 AND MET-241;
The covalent structure of a human gamma G-immunoglobulin. VII. Amino acid sequence of heavy-chain cyanogen bromide fragments H1-H4.
Cunningham B.A.; Rutishauser U.; Gall W.E.; Gottlieb P.D.; Waxdal M.J.; Edelman G.M.;
Cited for: PROTEIN SEQUENCE OF 1-135 (IMGT ALLELE IGHG1*03); VARIANT ARG-97;
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