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UniProtKB/Swiss-Prot P01857: Variant p.Lys97Arg

Immunoglobulin heavy constant gamma 1
Gene: IGHG1
Variant information

Variant position:  97
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  Polymorphism
The variants are classified into three categories: Disease, Polymorphism and Unclassified.
  • Disease: Variants implicated in disease according to literature reports.
  • Polymorphism: Variants not reported to be implicated in disease.
  • Unclassified: Variants with uncertain implication in disease according to literature reports. Evidence against or in favor of a pathogenic role is limited and/or conflicting.

Residue change:  From Lysine (K) to Arginine (R) at position 97 (K97R, p.Lys97Arg).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Similar physico-chemical property. Both residues are large size and basic.
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  2
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Polymorphism:  There are several alleles. The sequence shown is that of IMGT allele IGHG1*05.
Additional information on the polymorphism described.

Variant description:  In IMGT allele IGHG1*03.
Any additional useful information about the variant.



Sequence information

Variant position:  97
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  330
The length of the canonical sequence.

Location on the sequence:   GTQTYICNVNHKPSNTKVDK  K VEPKSCDKTHTCPPCPAPEL
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         GTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPC--PAPEL

Mouse                         PSETVTCNVAHPASSTKVDKKIVPRDCG----CKPCICTVP

Rat                           PSQTVTCNVAHPASSTKVDKKIVPRNCGGD--CKPCICTGS

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

TypePositionsDescription
Chain 1 – 330 Immunoglobulin heavy constant gamma 1
Domain 6 – 99 Ig-like 1
Region 1 – 98 CH1
Disulfide bond 103 – 103 Interchain (with light chain)
Disulfide bond 109 – 109 Interchain (with heavy chain)
Disulfide bond 112 – 112 Interchain (with heavy chain)
Beta strand 92 – 97


Literature citations

Three-dimensional structure determination of antibodies. Primary structure of crystallized monoclonal immunoglobulin IgG1 KOL, I.
Schmidt W.E.; Jung H.-D.; Palm W.; Hilschmann N.;
Hoppe-Seyler's Z. Physiol. Chem. 364:713-747(1983)
Cited for: PROTEIN SEQUENCE (IMGT ALLELE IGHG1*03); DISULFIDE BONDS; VARIANTS ARG-97; GLU-239 AND MET-241;

The covalent structure of a human gamma G-immunoglobulin. VII. Amino acid sequence of heavy-chain cyanogen bromide fragments H1-H4.
Cunningham B.A.; Rutishauser U.; Gall W.E.; Gottlieb P.D.; Waxdal M.J.; Edelman G.M.;
Biochemistry 9:3161-3170(1970)
Cited for: PROTEIN SEQUENCE OF 1-135 (IMGT ALLELE IGHG1*03); VARIANT ARG-97;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.