Variant position: 239 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 330 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human ISKAKGQPREPQVYTLPPSR DELTKNQVSLTCLVKGFYPSD
Mouse ISKTKGRPKAPQVYTIPPPK EQMAKDKVSLTCMITDFFPED
Rat ISKPEGRTQVPHVYTMSPTK EEMTQNEVSITCMVKGFYPPD
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Three-dimensional structure determination of antibodies. Primary structure of crystallized monoclonal immunoglobulin IgG1 KOL, I.
Schmidt W.E.; Jung H.-D.; Palm W.; Hilschmann N.;
Hoppe-Seyler's Z. Physiol. Chem. 364:713-747(1983)
Cited for: PROTEIN SEQUENCE (IMGT ALLELE IGHG1*03); DISULFIDE BONDS; VARIANTS ARG-97; GLU-239 AND MET-241;
The covalent structure of a human gamma G-immunoglobulin. 8. Amino acid sequence of heavy-chain cyanogen bromide fragments H5-H7.
Rutishauser U.; Cunningham B.A.; Bennett C.; Konigsberg W.H.; Edelman G.M.;
Cited for: PROTEIN SEQUENCE OF 136-329 (IMGT ALLELE IGHG1*03); VARIANTS GLU-239 AND MET-241;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.