Variant position: 215 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 453 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FTCRVDHRGLTFQQNA--SSMC VPDQ--DTAIRVFAIPPSFASIF
Mouse YTCRVDHRGLTFLKNV--SSTC AASP--STDILTFTIPPSF
Rabbit YTCRVDHRGIFFDKNVSMSSEC STTP--SPGIQVFPIAPSF
Chicken FSCVVEGE----MRNTSKRMEC GLEPVVQQDIAIRVITPSF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 453 Immunoglobulin heavy constant mu
106 – 217 CH2
209 – 209 N-linked (GlcNAc...) (complex) asparagine
214 – 214 Interchain (with heavy chain)
The primary structure of mu-chain-disease protein BOT. Peculiar amino-acid sequence of the N-terminal 42 positions.
Barnikol-Watanabe S.; Mihaesco E.; Mihaesco C.; Barnikol H.U.; Hilschmann N.;
Hoppe-Seyler's Z. Physiol. Chem. 365:105-118(1984)
Cited for: PROTEIN SEQUENCE OF 104-453; VARIANT GLY-215;
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