Sequence information
Variant position: 215 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 453 The length of the canonical sequence.
Location on the sequence:
FTCRVDHRGLTFQQNASSMC
V PDQDTAIRVFAIPPSFASIF
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human FTCRVDHRGLTFQQNA--SSMCV PDQ--DTAIRVFAIPPSFASIF
Mouse YTCRVDHRGLTFLKNV--SSTCA ASP--STDILTFTIPPSF
Rabbit YTCRVDHRGIFFDKNVSMSSECS TTP--SPGIQVFPIAPSF
Chicken FSCVVEGE----MRNTSKRMECG LEPVVQQDIAIRVITPSF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 453
Immunoglobulin heavy constant mu
Region
106 – 217
CH2
Glycosylation
209 – 209
N-linked (GlcNAc...) (complex) asparagine
Disulfide bond
214 – 214
Interchain (with heavy chain)
Literature citations
The primary structure of mu-chain-disease protein BOT. Peculiar amino-acid sequence of the N-terminal 42 positions.
Barnikol-Watanabe S.; Mihaesco E.; Mihaesco C.; Barnikol H.U.; Hilschmann N.;
Hoppe-Seyler's Z. Physiol. Chem. 365:105-118(1984)
Cited for: PROTEIN SEQUENCE OF 104-453; VARIANT GLY-215;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.