Variant position: 201 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1447 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TPIPGDSRVVVLPSGALQIS RLQPGDIGIYRCSARNPASSR
Mouse NPLPGDSRVVVLPSGALQIS RLQPGDSGVYRCSARNPASIR
Rat NPIPGDSRVVVLPSGALQIS RLQPGDSGVYRCSARNPASTR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis.
Miyake S.; Nagai K.; Yoshino K.; Oto M.; Endo M.; Yuasa Y.;
Cancer Res. 54:3007-3010(1994)
Cited for: VARIANTS THR-168 AND GLY-201; ROLE IN METASTATIC TUMOR DISSEMINATION;
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