Variant position: 152 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 847 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human IHLNVSERPFPPHIQLPPEI QESQEVTLTCLLNFSCYGYPI
Mouse IHLNVSEKPFQPYIQMPSEI RESQSVTLTCGLNFSCFEYDI
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
20 – 847 B-cell receptor CD22
20 – 687 Extracellular
143 – 235 Ig-like C2-type 1
135 – 135 N-linked (GlcNAc...) asparagine
164 – 164 N-linked (GlcNAc...) asparagine
39 – 167
4 – 175 Missing. In isoform 5.
Identification of the gene variations in human CD22.
Hatta Y.; Tsuchiya N.; Matsushita M.; Shiota M.; Hagiwara K.; Tokunaga K.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-137; 139-239; 241-328 AND 418-502; VARIANTS THR-34; GLU-152; LYS-203; GLY-664; CYS-669 AND ASP-745;
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