Variant position: 745 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 847 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SSGQSFFVRNKKVRRAPLSE GPHSLGCYNPMMEDGISYTTL
Mouse SSGQSFFVRNKKARRTPLSE GPQSQGCYNPAMDDTVSYAIL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
20 – 847 B-cell receptor CD22
707 – 847 Cytoplasmic
725 – 725 Phosphoserine
726 – 726 Phosphoserine
729 – 729 Phosphoserine
762 – 762 Phosphotyrosine
737 – 751 VRRAPLSEGPHSLGC -> RCRVLRDAETSPGLR. In isoform 4.
Identification of the gene variations in human CD22.
Hatta Y.; Tsuchiya N.; Matsushita M.; Shiota M.; Hagiwara K.; Tokunaga K.;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 13-137; 139-239; 241-328 AND 418-502; VARIANTS THR-34; GLU-152; LYS-203; GLY-664; CYS-669 AND ASP-745;
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