Sequence information
Variant position: 176 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 254 The length of the canonical sequence.
Location on the sequence:
DFYIPKATLKDSGSYFCRGL
F GSKNVSSETVNITITQGLAV
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DFYIPKATLKDSGSYFCRGLF GSKNVSSETVNITITQGLAV
Rhesus macaque DFYIPKATLKDSGSYFCRGLI GSKNVSSETVNITITQDLAV
Mouse ELLIPKATHNDSGSYFCRGLI GHNNKSSASFRISL-GDPGS
Rat ELSISKATHADSGSYFCRGII GRNNISSASLQISI-GDPTS
Pig EYHIPNATLKDGGSYFCRGII KNYDLSSEPVKVTV-QGSKS
Bovine DFHIPEAKLEHSGSYFCRGII GSKNESSESVQITV-QAPET
Rabbit DLHIPEATRNHSGSYFCRGLI GHHNMSSETVTITV-QGPAN
Cat DFYIPKATSKHSGSYFCRGLI GNKNESSEAVNITV-QGPPV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
17 – 254
Low affinity immunoglobulin gamma Fc region receptor III-A
Topological domain
17 – 208
Extracellular
Domain
107 – 189
Ig-like C2-type 2
Glycosylation
180 – 180
N-linked (GlcNAc...) asparagine
Glycosylation
187 – 187
N-linked (GlcNAc...) asparagine
Beta strand
168 – 176
Literature citations
Submission
Suzuki Y.; Sugano S.; Totoki Y.; Toyoda A.; Takeda T.; Sakaki Y.; Tanaka A.; Yokoyama S.;
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT VAL-176;
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
The MGC Project Team;
Genome Res. 14:2121-2127(2004)
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]; VARIANT VAL-176;
Human glomerular mesangial cells express CD16 and may be stimulated via this receptor.
Morcos M.; Hansch G.M.; Schonermark M.; Ellwanger S.; Harle M.; Heckl-Ostreicher B.;
Kidney Int. 46:1627-1634(1994)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-254; VARIANT VAL-176;
Fc gammaRIIIa-158V/F polymorphism influences the binding of IgG by natural killer cell Fc gammaRIIIa, independently of the Fc gammaRIIIa-48L/R/H phenotype.
Koene H.R.; Kleijer M.; Algra J.; Roos D.; von dem Borne A.E.G.K.; de Haas M.;
Blood 90:1109-1114(1997)
Cited for: VARIANT VAL-176; FUNCTION; SUBUNIT;
A novel polymorphism of FcgammaRIIIa (CD16) alters receptor function and predisposes to autoimmune disease.
Wu J.; Edberg J.C.; Redecha P.B.; Bansal V.; Guyre P.M.; Coleman K.; Salmon J.E.; Kimberly R.P.;
J. Clin. Invest. 100:1059-1070(1997)
Cited for: VARIANT VAL-176;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.