Variant position: 49 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 110 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human HLCGSHLVEALYLVCGERGF FYTPKTRREAEDLQVG--QVELG
Gorilla HLCGSHLVEALYLVCGERGF FYTPKTRREAEDLQVG--QVE
Chimpanzee HLCGSHLVEALYLVCGERGF FYTPKTRREAEDLQVG--QVE
Pig HLCGSHLVEALYLVCGERGF FYTPKARREAENPQAG--AVE
Bovine HLCGSHLVEALYLVCGERGF FYTPKARREVEGPQVG--ALE
Rabbit HLCGSHLVEALYLVCGERGF FYTPKSRREVEELQVG--QAE
Goat HLCGSHLVEALYLVCGERGF FYTPKA---------------
Sheep HLCGSHLVEALYLVCGERGF FYTPKARREVEGPQVG--ALE
Cat HLCGSHLVEALYLVCGERGF FYTPKARREAEDLQGK--DAE
Horse HLCGSHLVEALYLVCGERGF FYTPKAXXEAEDPQVG--EVE
Chicken HLCGSHLVEALYLVCGERGF FYSPKARRDVEQPLVS--SPL
Zebrafish HLCGSHLVDALYLVCGPTGF FYNPK--RDVE-PLLGFLPPK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
25 – 54 Insulin B chain
31 – 96 Interchain (between B and A chains)
43 – 109 Interchain (between B and A chains)
48 – 50
Identification of a mutant human insulin predicted to contain a serine-for-phenylalanine substitution.
Shoelson S.; Fickova M.; Haneda M.; Nahum A.; Musso G.; Kaiser E.T.; Rubenstein A.H.; Tager H.;
Proc. Natl. Acad. Sci. U.S.A. 80:7390-7394(1983)
Cited for: VARIANTS LOS ANGELES SER-48 AND CHICAGO LEU-49;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.