Sequence information
Variant position: 89 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 110 The length of the canonical sequence.
Location on the sequence:
GGGPGAGSLQPLALEGSLQK
R GIVEQCCTSICSLYQLENYC
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GGGPGAGSLQPLALEGSLQKR GIVEQCCTSICSLYQLENYC
Gorilla GGGPGAGSLQPLALEGSLQKR GIVEQCCTSICSLYQLENYC
AGAPGEGGLQPLALEGALQKR GIVEQCCTSICSLYQLENYC
Chimpanzee GGGPGAGSLQPLALEGSLQKR GIVEQCCTSICSLYQLENYC
Pig GG--GLGGLQALALEGPPQKR GIVEQCCTSICSLYQLENYC
Bovine AGGPGAGGL-----EGPPQKR GIVEQCCASVCSLYQLENYC
Rabbit GGGPGAGGLQPSALELALQKR GIVEQCCTSICSLYQLENYC
Goat --------------------- GIVEQCCAGVCSLYQLENYC
Sheep AGGPGAGGL-----EGPPQKR GIVEQCCAGVCSLYQLENYC
Cat GEAPGAGGLQPSALEAPLQKR GIVEQCCASVCSLYQLEHYC
Horse GGGPGLGGLQPLALAGPQQXX GIVEQCCTGICSLYQLENYC
Chicken GE---AGVLPFQQEEYEKVKR GIVEQCCHNTCSLYQLENYC
Zebrafish AQETEVADFAFKDHAELIRKR GIVEQCCHKPCSIFELQNYC
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Disulfide bond
31 – 96
Interchain (between B and A chains)
Disulfide bond
43 – 109
Interchain (between B and A chains)
Literature citations
A novel point mutation in the human insulin gene giving rise to hyperproinsulinemia (proinsulin Kyoto).
Yano H.; Kitano N.; Morimoto M.; Polonsky K.S.; Imura H.; Seino Y.;
J. Clin. Invest. 89:1902-1907(1992)
Cited for: VARIANT HPRI LEU-89;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.