Variant position: 92 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 110 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PGAGSLQPLALEGSLQKRGI VEQCCTSICSLYQLENYCN
Gorilla PGAGSLQPLALEGSLQKRGI VEQCCTSICSLYQLENYCN
Chimpanzee PGAGSLQPLALEGSLQKRGI VEQCCTSICSLYQLENYCN
Pig -GLGGLQALALEGPPQKRGI VEQCCTSICSLYQLENYCN
Bovine PGAGGL-----EGPPQKRGI VEQCCASVCSLYQLENYCN
Rabbit PGAGGLQPSALELALQKRGI VEQCCTSICSLYQLENYCN
Goat ------------------GI VEQCCAGVCSLYQLENYCN
Sheep PGAGGL-----EGPPQKRGI VEQCCAGVCSLYQLENYCN
Cat PGAGGLQPSALEAPLQKRGI VEQCCASVCSLYQLEHYCN
Horse PGLGGLQPLALAGPQQXXGI VEQCCTGICSLYQLENYCN
Chicken --AGVLPFQQEEYEKVKRGI VEQCCHNTCSLYQLENYCN
Zebrafish TEVADFAFKDHAELIRKRGI VEQCCHKPCSIFELQNYCN
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
90 – 110 Insulin A chain
31 – 96 Interchain (between B and A chains)
43 – 109 Interchain (between B and A chains)
91 – 97
Structurally abnormal insulin in a diabetic patient. Characterization of the mutant insulin A3 (Val-->Leu) isolated from the pancreas.
Sakura H.; Iwamoto Y.; Sakamoto Y.; Kuzuya T.; Hirata H.;
J. Clin. Invest. 78:1666-1672(1986)
Cited for: VARIANT WAKAYAMA LEU-92;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.