Variant position: 874 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1039 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GLQCFPQPPVNPLKVDWGLP IPSPSPIHPAHHKRDRRQIFL
Mouse GLLCSTQPSP---KVDWKLS TPSPSSIRPVHHQRERRQAFL
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
32 – 1039 Integrin alpha-IIb
32 – 887 Integrin alpha-IIb heavy chain
32 – 993 Extracellular
891 – 891 Pyrrolidone carboxylic acid; in light chain form 1
874 – 874 O-linked (GalNAc...) serine; in variant S-874
878 – 878 O-linked (GalNAc...) serine
857 – 911 Interchain (between heavy and light chains)
Characterization of single-nucleotide polymorphisms in coding regions of human genes.
Cargill M.; Altshuler D.; Ireland J.; Sklar P.; Ardlie K.; Patil N.; Shaw N.; Lane C.R.; Lim E.P.; Kalyanaraman N.; Nemesh J.; Ziaugra L.; Friedland L.; Rolfe A.; Warrington J.; Lipshutz R.; Daley G.Q.; Lander E.S.;
Nat. Genet. 22:231-238(1999)
Cited for: VARIANTS ILE-40; SER-874 AND ASN-968; POLYMORPHISM;
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