Variant position: 778 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 788 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human EERARAKWDTANNPLYKEAT STFTNITYRGT
Mouse EERARAKWDTANNPLYKEAT STFTNITYRGT
Rat EERARAKWDTANNPLYKEAT STFTNITYRGT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
27 – 788 Integrin beta-3
742 – 788 Cytoplasmic
767 – 767 Phosphothreonine
773 – 773 Phosphotyrosine
779 – 779 Phosphothreonine; by PDPK1 and PKB/AKT1; in vitro
785 – 785 Phosphotyrosine
768 – 788 ANNPLYKEATSTFTNITYRGT -> VRDGAGRFLKSLV. In isoform Beta-3B.
768 – 788 ANNPLYKEATSTFTNITYRGT -> HYAQSLRKWNQPVSIDG. In isoform Beta-3C.
776 – 779
Ser-752-->Pro mutation in the cytoplasmic domain of integrin beta 3 subunit and defective activation of platelet integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) in a variant of Glanzmann thrombasthenia.
Chen Y.-P.; Djaffar I.; Pidard D.; Steiner B.; Cieutat A.-M.; Caen J.P.; Rosa J.-P.;
Proc. Natl. Acad. Sci. U.S.A. 89:10169-10173(1992)
Cited for: VARIANT GT PRO-778;
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