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UniProtKB/Swiss-Prot P01579: Variant p.Arg160Gln

Interferon gamma
Gene: IFNG
Variant information

Variant position:  160
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Type of variant:  LB/B
The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance

Residue change:  From Arginine (R) to Glutamine (Q) at position 160 (R160Q, p.Arg160Gln).
Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.

Physico-chemical properties:  Change from large size and basic (R) to medium size and polar (Q)
The physico-chemical property of the reference and variant residues and the change implicated.

BLOSUM score:  1
The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page

Other resources:  
Links to websites of interest for the variant.

Sequence information

Variant position:  160
The position of the amino-acid change on the UniProtKB canonical protein sequence.

Protein sequence length:  166
The length of the canonical sequence.

Location on the sequence:   MAELSPAAKTGKRKRSQMLF  R GRRASQ
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.

Residue conservation: 
The multiple alignment of the region surrounding the variant against various orthologous sequences.

Human                         MAELSPAAKTGKRKRSQMLFRGRRASQ-


Rhesus macaque                MAELSPAAKIGKRKRSQM-FRGRRASQ

Mouse                         VHQLLPESSLRKRKRSRC---------

Rat                           IHQLSPESSLRKRKRSRC---------

Pig                           MNDLSPRSNLRKRKRSQTMFQGQRASK

Bovine                        MNDLSPKSNLRKRKRSQNLFRGRRASM

Rabbit                        LNFLSPKSNLKKRKRSQTLFRGRRASK

Goat                          MNDLSPKSNLRKRKRSQNLFRGRRASM

Sheep                         MNDLSPKSNLRKRKRSQNLFRGRRASM

Cat                           MNDLSPRSNLRKRKRSQNLFRGRRASK

Horse                         MNDLSPKANLRKRKRSQNPFRGRRALQ

Chicken                       LQKLVDPPSF-KRKRSQS---QRRCNC

Sequence annotation in neighborhood:  
The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.

Chain 24 – 161 Interferon gamma
Region 147 – 166 Disordered

Literature citations

Chikara S.K.; Jaiswal P.; Sharma G.;

Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.