Variant position: 149 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 610 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RCSKKKLALCYTAACTNTSC SGHGECVETINNYTCKCDPGF
Mouse RCNKKKLALCYTASCTNASC SGHGECIETINSYTCKCHPGF
Rat RCDKKKLALCYTASCTNTSC SGHGECVETINSYTCKCHPGF
Pig RCSKKKLALCYTAACTPTSC SGHGECIETINSSTCQCYPGF
Bovine KCTKQKLALCYKAACNPTPC GSHGECVETINNYTCQCHPGF
Rabbit RCSKKKLALCYTAACTEASC SGHGECIETINNYSCKCYPGF
Horse NCNKKKLALCYTAACTHTSC SGHGECVETINNYTCQCHPGF
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
SeattleSNPs variation discovery resource;
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS SER-21; ILE-31; ARG-149; PRO-257; LYS-295; GLN-421; TYR-468; SER-550 AND PHE-575;
E-selectin polymorphism and atherosclerosis: an association study.
Wenzel K.; Felix S.; Kleber F.X.; Brachold R.; Menke T.; Schattke S.; Schulte K.L.; Glaser C.; Rohde K.; Baumann G.; Speer A.;
Hum. Mol. Genet. 3:1935-1937(1994)
Cited for: VARIANT ARG-149;
DNA polymorphisms in adhesion molecule genes -- a new risk factor for early atherosclerosis.
Wenzel K.; Ernst M.; Rohde K.; Baumann G.; Speer A.;
Hum. Genet. 97:15-20(1996)
Cited for: VARIANTS ARG-149 AND PHE-575;
A PstI polymorphism detects the mutation of serine-128 to arginine in CD 62E gene - a risk factor for coronary artery disease.
Ye S.Q.; Usher D.; Virgil D.; Zhang L.Q.; Yochim S.E.; Gupta R.;
J. Biomed. Sci. 6:18-21(1999)
Cited for: VARIANT ARG-149;
Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis.
Halushka M.K.; Fan J.-B.; Bentley K.; Hsie L.; Shen N.; Weder A.; Cooper R.; Lipshutz R.; Chakravarti A.;
Nat. Genet. 22:239-247(1999)
Cited for: VARIANTS ARG-149; TYR-468 AND PHE-575;
E-selectin polymorphism associated with myocardial infarction causes enhanced leukocyte-endothelial interactions under flow conditions.
Yoshida M.; Takano Y.; Sasaoka T.; Izumi T.; Kimura A.;
Arterioscler. Thromb. Vasc. Biol. 23:783-788(2003)
Cited for: VARIANT ARG-149; SUBCELLULAR LOCATION; CHARACTERIZATION OF VARIANT ARG-149;
Implications of the E-selectin S128R mutation for drug discovery.
Preston R.C.; Rabbani S.; Binder F.P.; Moes S.; Magnani J.L.; Ernst B.;
Cited for: CHARACTERIZATION OF VARIANT ARG-149;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.