Variant position: 56 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 190 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QDKFLGRWFSAGLASNSSWL REKKAALSMCKSVVAPATDGG
Gorilla QDKFLGRWFSAGLASNSSWL REKKAALSMCKSVVAPAADGG
Mouse QDKFLGRWYSAGLASNSSWF REKKAVLYMCKTVVAPSTEGG
Rat QDKFLGRWYSAGLASNSSWF REKKELLFMCQTVVAPSTEGG
Pig EDKFLGRWFTSGLASNSSWF LEKKKVLSMCKSLVAPAPDGG
Bovine EDKFLGRWFTSGLASNSSWF LEKKKVLSMCKSVVAPAADGG
Sheep EDKFLGRWFTSGLASNSSWF LEKRKVLSMCKSEVAPAADGG
Cat QDKFLGRWFTSGLASNSSWF REKKNALSMCISVVAPSAEGG
Horse QDKFLGRWFTSGLASNSSWF REKKKVLSMCTSVVAPTADGG
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
23 – 190 Prostaglandin-H2 D-isomerase
65 – 65 Nucleophile
51 – 51 N-linked (GlcNAc...) (complex) asparagine
59 – 59 K -> A. Increases enzyme activity about two-fold.
64 – 64 M -> A. Reduces enzyme activity almost ten-fold.
65 – 65 C -> A. Loss of enzyme activity.
53 – 60
No reference for the current variant in UniProtKB/Swiss-Prot.
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.