Variant position: 920 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1265 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NLKDEYFEEIMEEYEDIRQD HYESLKERRYLPLSQARKSGF
Mouse NLRDDYFEEILEEYEDIRQD HYESLKERKYVPLSQARKHGF
Rat NLKDDYFEEILEEYEDIRQD HYESLKERKYLPLSQARKHSF
Bovine NLKDEYFEEILEEYEDIRQD HYESLKERRYLTLRQARENGF
Caenorhabditis elegans SVRDAFLQDLNEDYEDVRQE HYASLKDRRFTDLNKTREKKF
Slime mold NNKEVFAEDVSQQYAELREK HYASLKDRKYTSLEKARQHCV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1265 Methionine synthase
Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders.
Leclerc D.; Campeau E.; Goyette P.; Adjalla C.E.; Christensen B.; Ross M.; Eydoux P.; Rosenblatt D.S.; Rozen R.; Gravel R.A.;
Hum. Mol. Genet. 5:1867-1874(1996)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS HMAG ILE-881 DEL AND ASP-920;
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