Variant position: 1173 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1265 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human CGSEQLDVADLRRLRYKGIR PAPGYPSQPDHTEKLTMWRLA
Mouse SRSEQLGVPDLRRLRYEGIR PAPGYPSQPDHTEKLTMWRLA
Rat CGSEQLGVTDLRKLRYEGIR PAPGYPSQPDHTEKLTMWRLA
Bovine CSGEQLAVADLRRLRYEGIR PAPGYPSQPDHTEKLTVWRLA
Caenorhabditis elegans STNEDLTESDLLSIKYQGIR PACGYPSQPDHTEKRTLWKLL
Slime mold EKDQALSNEDLFKIKYKGIR PAPGYPAQPDHTEMKTIWSLM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 1265 Methionine synthase
923 – 1265 AdoMet activation
1172 – 1172 S-adenosyl-L-methionine; via carbonyl oxygen
Defects in human methionine synthase in cblG patients.
Gulati S.; Baker P.J.; Li Y.N.; Fowler B.; Kruger W.D.; Brody L.C.; Banerjee R.;
Hum. Mol. Genet. 5:1859-1865(1996)
Cited for: VARIANTS HMAG ILE-881 DEL AND LEU-1173; VARIANT LYS-61;
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