Variant position: 106 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 301 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human DGNLVVRPYTPISSDDDKGF VDLVIKVYFKDTHPKFPAGGK
Mouse DGNLVIRPYTPVSSDDDKGF VDLVVKVYFKDTHPKFPAGGK
Rat DGNLVIRPYTPVSSDDDKGF VDLVVKVYFKDTHPKFPAGGK
Bovine DGNLVIRPYTPVSSDDDKGF VDLVIKVYFKDTHPKFPAGGK
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
2 – 301 NADH-cytochrome b5 reductase 3 membrane-bound form
27 – 301 NADH-cytochrome b5 reductase 3 soluble form
40 – 152 FAD-binding FR-type
120 – 120 N6-acetyllysine
104 – 111
Enzymatic instability of NADH-cytochrome b5 reductase as a cause of hereditary methemoglobinemia type I (red cell type).
Shirabe K.; Yubisui T.; Borgese N.; Tang C.-Y.; Hultquist D.E.; Takeshita M.;
J. Biol. Chem. 267:20416-20421(1992)
Cited for: VARIANT METHB-CYB5R3 MET-106;
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