Variant position: 438 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 461 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human WPKLLMKVTDLRMIGACHAS RFLHMKVECPTELFPPLFLEV
Mouse WPKLLMKVTDLRMIGACHAS RFLHMKVECPTELFPPLFLEV
Rat WPKLLMKVTDLRMIGACHAS RFLHMKVECPTELFPPLFLEV
Chicken WPKLLMKVTDLRMIGACHAS RFLHMKVECPTELFPPLFLEV
Zebrafish WPKLLMKVTDLRMIGACHAS RFLHMKVECPTELFPPLFLEV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Identical mutations in unrelated families with generalized resistance to thyroid hormone occur in cytosine-guanine-rich areas of the thyroid hormone receptor beta gene. Analysis of 15 families.
Weiss R.E.; Weinberg M.; Refetoff S.;
J. Clin. Invest. 91:2408-2415(1993)
Cited for: VARIANTS GTHR THR-317; CYS-320; HIS-320; TRP-338; HIS-438 AND THR-453;
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