Sequence information
Variant position: 733 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 920 The length of the canonical sequence.
Location on the sequence:
LVHVVKWAKALPGFRNLHVD
D QMAVIQYSWMGLMVFAMGWR
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LVHVVKWAKALPGFRNLHVDD QMAVIQYSWMGLMVFAMGWR
LVHVVKWAKALPGFRNLHVDD QMAVIQYSWMGLMVFAMGWR
Rhesus macaque LVHVVKWAKALPGFRNLHVDD QMAVIQYSWMGLMVFAMGWR
Chimpanzee LVHVVKWAKALPGFRNLHVDD QMAVIQYSWMGLMVFAMGWR
Mouse LVHVVKWAKALPGFRNLHVDD QMAVIQYSWMGLMVFAMGWR
Rat LVHVVKWAKALPGFRNLHVDD QMAVIQYSWMGLMVFAMGWR
Pig LVHVVKWAKALPGFRNLHVDD QMAVIQYSWMGLMVFAMGWR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 920
Androgen receptor
Domain
669 – 900
NR LBD
Region
552 – 919
Interaction with LPXN
Region
592 – 919
Interaction with CCAR1
Region
625 – 919
Interaction with KAT7
Binding site
753 – 753
17beta-hydroxy-5alpha-androstan-3-one
Site
721 – 721
Interaction with coactivator LXXL and FXXFY motifs
Alternative sequence
645 – 920
Missing. In isoform 3.
Alternative sequence
649 – 920
Missing. In isoform 4.
Mutagenesis
721 – 721
K -> A. Loss of transcription activation in the presence of androgen and of interaction with NCOA2.
Mutagenesis
742 – 742
W -> L. Strongly decreased transcription activation in the presence of androgen.
Helix
731 – 758
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.