Variant position: 870 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 920 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human PTSCSRRFYQLTKLLDSVQP IARELHQFTFDLLIKSHMVSV
Rhesus macaque PTSCSRRFYQLTKLLDSVQP IARELHQFTFDLLIKSHMVSV
Chimpanzee PTSCSRRFYQLTKLLDSVQP IARELHQFTFDLLIKSHMVSV
Mouse PTSCSRRFYQLTKLLDSVQP IARELHQFTFDLLIKSHMVSV
Rat PTSCSRRFYQLTKLLDSVQP IARELHQFTFDLLIKSHMVSV
Pig PTSCSRRFYQLTKLLDSVQP IARELHQFTFDLLIKSHMVSV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Mutations of the androgen receptor gene identified in perineal hypospadias.
Batch J.A.; Evans B.A.J.; Hughes I.A.; Patterson M.N.;
J. Med. Genet. 30:198-201(1993)
Cited for: INVOLVEMENT IN PAIS; INVOLVEMENT IN HYSP1; VARIANTS PAIS HIS-856 AND MET-870;
Functional analysis of six androgen receptor mutations identified in patients with partial androgen insensitivity syndrome.
Bevan C.L.; Brown B.B.; Davies H.R.; Evans B.A.J.; Hughes I.A.; Patterson M.N.;
Hum. Mol. Genet. 5:265-273(1996)
Cited for: VARIANTS PAIS ILE-743; ILE-781; GLU-799; CYS-841; HIS-856 AND MET-870;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.