Variant position: 15 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 348 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MNGTEGPNFYVPFS NATGVVRSPFEYPQYYLAEPW
Mouse MNGTEGPNFYVPFS NVTGVVRSPFEQPQYYLAEPW
Rat MNGTEGPNFYVPFS NITGVVRSPFEQPQYYLAEPW
Pig MNGTEGPNFYVPFS NKTGVVRSPFEYPQYYLAEPW
Bovine MNGTEGPNFYVPFS NKTGVVRSPFEAPQYYLAEPW
Rabbit MNGTEGPDFYIPMS NQTGVVRSPFEYPQYYLAEPW
Sheep MNGTEGPNFYVPFS NKTGVVRSPFEAPQYYLAEPW
Cat MNGTEGPNFYVPFS NKTGVVRSPFEYPQYYLAEPW
Chicken MNGTEGQDFYVPMS NKTGVVRSPFEYPQYYLAEPW
Xenopus laevis MNGTEGPNFYVPMS NKTGVVRSPFDYPQYYLAEPW
Zebrafish MNGTEGPAFYVPMS NATGVVRSPYEYPQYYLVAPW
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 348 Rhodopsin
1 – 36 Extracellular
1 – 1 N-acetylmethionine
2 – 2 N-linked (GlcNAc...) asparagine
15 – 15 N-linked (GlcNAc...) asparagine
Autosomal dominant 'sector' retinitis pigmentosa due to a point mutation predicting an Asn-15-Ser substitution of rhodopsin.
Kranich H.; Bartkowski S.; Denton M.J.; Krey S.; Dickinson P.; Duvigneau C.; Gal A.;
Hum. Mol. Genet. 2:813-814(1993)
Cited for: VARIANT RP4 SER-15;
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