Variant position: 90 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 348 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TPLNYILLNLAVADLFMVLG GFTSTLYTSLHGYFVFGPTGC
Mouse TPLNYILLNLAVADLFMVFG GFTTTLYTSLHGYFVFGPTGC
Rat TPLNYILLNLAVADLFMVFG GFTTTLYTSLHGYFVFGPTGC
Pig TPLNYILLNLAVADLFMVFG GFTTTLYTSLHGYFVFGPTGC
Bovine TPLNYILLNLAVADLFMVFG GFTTTLYTSLHGYFVFGPTGC
Rabbit TPLNYILLNLAVADLFMVLG GFTTTLYTSLHGYFVFGPTGC
Sheep TPLNYILLNLAVADLFMVFG GFTTTLYTSLHGYFVFGPTGC
Cat TPLNYILLNLAVADLFMVFG GFTTTLYTSLHGYFVFGPTGC
Chicken TPLNYILLNLVVADLFMVFG GFTTTMYTSMNGYFVFGVTGC
Xenopus laevis TPLNYILLNLVFANHFMVLC GFTVTMYTSMHGYFIFGPTGC
Zebrafish TPLNYILLNLAIADLFMVFG GFTTTMYTSLHGYFVFGRLGC
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness.
Rao V.R.; Cohen G.B.; Oprian D.D.;
Cited for: CHARACTERIZATION OF VARIANT CSNBAD1 ASP-90; FUNCTION;
Dark-light: model for nightblindness from the human rhodopsin Gly-90-->Asp mutation.
Sieving P.A.; Richards J.E.; Naarendorp F.; Bingham E.L.; Scott K.; Alpern M.;
Proc. Natl. Acad. Sci. U.S.A. 92:880-884(1995)
Cited for: VARIANT CSNBAD1 ASP-90; FUNCTION;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.