Variant position: 106 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 348 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human MVLGGFTSTLYTSLHGYFVF GPTGCNLEGFFATLGGEIALW
Mouse MVFGGFTTTLYTSLHGYFVF GPTGCNLEGFFATLGGEIALW
Rat MVFGGFTTTLYTSLHGYFVF GPTGCNLEGFFATLGGEIGLW
Pig MVFGGFTTTLYTSLHGYFVF GPTGCNLEGFFATLGGEIALW
Bovine MVFGGFTTTLYTSLHGYFVF GPTGCNLEGFFATLGGEIALW
Rabbit MVLGGFTTTLYTSLHGYFVF GPTGCNVEGFFATLGGEIALW
Sheep MVFGGFTTTLYTSLHGYFVF GPTGCNLEGFFATLGGEIALW
Cat MVFGGFTTTLYTSLHGYFVF GPTGCNLEGFFATLGGEIALW
Chicken MVFGGFTTTMYTSMNGYFVF GVTGCYIEGFFATLGGEIALW
Xenopus laevis MVLCGFTVTMYTSMHGYFIF GPTGCYIEGFFATLGGEVALW
Zebrafish MVFGGFTTTMYTSLHGYFVF GRLGCNLEGFFATLGGEMGLW
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
1 – 348 Rhodopsin
97 – 110 Extracellular
113 – 113 Plays an important role in the conformation switch to the active conformation
113 – 113 E -> Q. Induces a conformation change that promotes interaction with GRK1 and SAG; when associated with Y-257.
106 – 140
No reference for the current variant in UniProtKB/Swiss-Prot.
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