Variant position: 140 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 348 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human GGEIALWSLVVLAIERYVVV CKPMSNFRFGENHAIMGVAFT
Mouse GGEIALWSLVVLAIERYVVV CKPMSNFRFGENHAIMGVVFT
Rat GGEIGLWSLVVLAIERYVVV CKPMSNFRFGENHAIMGVAFT
Pig GGEIALWSLVVLAIERYVVV CKPMSNFRFGENHAIMGLALT
Bovine GGEIALWSLVVLAIERYVVV CKPMSNFRFGENHAIMGVAFT
Rabbit GGEIALWSLVVLAIERYVVV CKPMSNFRFGENHAIMGVAFT
Sheep GGEIALWSLVVLAIERYVVV CKPMSNFRFGENHAIMGVAFT
Cat GGEIALWSLVVLAIERYVVV CKPMSNFRFGENHAIMGVAFT
Chicken GGEIALWSLVVLAVERYVVV CKPMSNFRFGENHAIMGVAFS
Xenopus laevis GGEVALWSLVVLAVERYIVV CKPMANFRFGENHAIMGVAFT
Zebrafish GGEMGLWSLVVLAIERWMVV CKPVSNFRFGENHAIMGVAFT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Identification of novel rhodopsin mutations responsible for retinitis pigmentosa: implications for the structure and function of rhodopsin.
Macke J.P.; Davenport C.M.; Jacobson S.G.; Hennessey J.C.; Gonzalez-Fernandez F.; Conway B.P.; Heckenlively J.; Palmer R.; Maumenee I.H.; Sieving P.; Gouras P.; Good W.; Nathans J.;
Am. J. Hum. Genet. 53:80-89(1993)
Cited for: VARIANTS RP4 ARG-106; GLY-135; SER-140; GLU-188 AND ARG-211; VARIANTS ALA-51; ILE-104 AND MET-209;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.