Variant position: 79 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 354 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human LSADLKFRIKQ------KGEYLPLLQ GKSLGMIFEKRSTRTRLSTET
Mouse LSADLKFRIKQ------KGEYLPLLQ GKSLGMIFEKRSTRT
Rat LSADLKFRIKQ------KGEYLPLLQ GKSLGMIFEKRSTRT
Bovine LSADLKFRIKQ------KGEYLPLLQ GKSLGMIFEKRSTRT
Sheep LSADLKFRIKQ------KGEYLPLLQ GKSLGMIFEKRSTRT
Chicken VASDLKQRIKD------KGEYLPLMQ GKSLAMIFEKRSTRT
Baker's yeast RAQHFKNVFKANKTNDFQSNHLKLL- GRTIALIFTKRSTRT
Fission yeast RSSEIKQAYKQNFQNR-RSVQMSGLS SQNVAMIFSKRSTRT
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
33 – 354 Ornithine carbamoyltransferase, mitochondrial
70 – 70 N6-acetyllysine; alternate
70 – 70 N6-succinyllysine; alternate
80 – 80 N6-succinyllysine
88 – 88 N6-acetyllysine; alternate
88 – 88 N6-succinyllysine; alternate
76 – 79
Six new mutations in the ornithine transcarbamylase gene detected by single-strand conformational polymorphism.
Tuchman M.; Holzknecht R.A.; Gueron A.B.; Berry S.A.; Tsai M.Y.;
Pediatr. Res. 32:600-604(1992)
Cited for: VARIANTS OTCD GLU-79; THR-94; PHE-304 AND ASP-345;
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