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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P21953: Variant p.His206Arg

2-oxoisovalerate dehydrogenase subunit beta, mitochondrial
Gene: BCKDHB
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Variant information Variant position: help 206 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance
Residue change: help From Histidine (H) to Arginine (R) at position 206 (H206R, p.His206Arg). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from medium size and polar (H) to large size and basic (R) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 0 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page
Variant description: help In MSUD1B; loss of 3-methyl-2-oxobutanoate dehydrogenase activity. Any additional useful information about the variant.


Sequence information Variant position: help 206 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 392 The length of the canonical sequence.
Location on the sequence: help WGCVGHGALYHSQSPEAFFA H CPGIKVVIPRSPFQAKGLLL The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences. 
Human                         WGCVGHGALYHSQSPEAFFAHCPGIKVVIPRSPFQAKGLLL

Mouse                         WGCVGHGALYHSQSPEAFFAHCPGIKVVIPRSPFQAKGLLL

Rat                           WGCVGHGALYHSQSPEAFFAHCPGIKVVIPRSPFQAKGLLL

Bovine                        WGCVGHGALYHSQSPEAFFAHCPGIKVVVPRSPFQAKGLLL

Slime mold                    YGAVGHGGHYHSQSPESYFGHTPGLKVVIPSTPIEAKGLLL
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 51 – 392 2-oxoisovalerate dehydrogenase subunit beta, mitochondrial



Literature citations
Crystal structure of human branched-chain alpha-ketoacid dehydrogenase and the molecular basis of multienzyme complex deficiency in maple syrup urine disease.
Aevarsson A.; Chuang J.L.; Wynn R.M.; Turley S.; Chuang D.T.; Hol W.G.J.;
Structure 8:277-291(2000)
Cited for: X-RAY CRYSTALLOGRAPHY (2.70 ANGSTROMS) OF 51-392 IN COMPLEX WITH BCKDHA; THIAMINE PYROPHOSPHATE AND POTASSIUM IONS; FUNCTION; CATALYTIC ACTIVITY; COFACTOR; SUBUNIT; SUBCELLULAR LOCATION; VARIANT MSUD1B TYR-176; CHARACTERIZATION OF VARIANT MSUD1B TYR-176 AND ARG-206; Heterogeneity of mutations in maple syrup urine disease (MSUD): screening and identification of affected E1 alpha and E1 beta subunits of the branched-chain alpha-keto-acid dehydrogenase multienzyme complex.
Nobukuni Y.; Mitsubuchi H.; Hayashida Y.; Ohta K.; Indo Y.; Ichiba Y.; Endo F.; Matsuda I.;
Biochim. Biophys. Acta 1225:64-70(1993)
Cited for: VARIANT MSUD1B ARG-206;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.