Variant position: 534 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 1025 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human SVSA-KPELPLFYTPIDLVDI SVEMAGLKFINPFGLASATPA
Mouse SVPS-QPTMPLFYTPVDLVDI SVEMAGLRFPNPFGLASATP
Rat LVPS-QPTLPLFYTPVDLVDI SVEMAGLRFPNPFGLASATP
Pig SVSA-KPELPLFYTPVDLVDI SVEMAGLKFINPFGLASAAP
Bovine SVSA-KPELPLFYTPIDLVDI SVEMAALKFTNPFGLASATP
Zebrafish TISA-TPRLPLFHCSIDTVDI SVEMCGIKFPNPFGLASAPP
Caenorhabditis elegans QVSE-TPELPQFFTPIDEVDI SVDMCGVKFENPFGLASAPP
Slime mold PIPDGPPQLPNFFTPIDLVDI SVEMCGMKFPNPFGLASATP
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
4 – 1025 Dihydropyrimidine dehydrogenase [NADP(+)]
550 – 550 FMN
174 – 1025 Missing. In isoform 2.
Dihydropyrimidine dehydrogenase pharmacogenetics in patients with colorectal cancer.
Ridge S.A.; Sludden J.; Wei X.; Sapone A.; Brown O.; Hardy S.; Canney P.; Fernandez-Salguero P.; Gonzalez F.J.; Cassidy J.; McLeod H.L.;
Br. J. Cancer 77:497-500(1998)
Cited for: VARIANTS ASN-534 AND VAL-543;
Dihydropyrimidine dehydrogenase pharmacogenetics in Caucasian subjects.
Ridge S.A.; Sludden J.; Brown O.; Robertson L.; Wei X.; Sapone A.; Fernandez-Salguero P.M.; Gonzalez F.J.; Vreken P.; van Kuilenburg A.B.; van Gennip A.H.; McLeod H.L.;
Br. J. Clin. Pharmacol. 46:151-156(1998)
Cited for: VARIANTS ASN-534; VAL-543 AND ILE-732;
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.