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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot Q12882: Variant p.Arg886His

Dihydropyrimidine dehydrogenase [NADP(+)]
Gene: DPYD
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Variant information Variant position: help 886 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: help LP/P [Disclaimer] The variants are classified into three categories: LP/P, LB/B and US.
  • LP/P: likely pathogenic or pathogenic.
  • LB/B: likely benign or benign.
  • US: uncertain significance
Residue change: help From Arginine (R) to Histidine (H) at position 886 (R886H, p.Arg886His). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: help Change from large size and basic (R) to medium size and polar (H) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: help 0 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:
  • Lowest score: -4 (low probability of substitution).
  • Highest score: 11 (high probability of substitution).
More information can be found on the following page
Variant description: help In DPYDD; allele DPYD*9B; 25% of activity. Any additional useful information about the variant.
Other resources: help Links to websites of interest for the variant.


Sequence information Variant position: help 886 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: help 1025 The length of the canonical sequence.
Location on the sequence: help PRIAELMDKKLPSFGPYLEQ R KKIIAENKIRLKEQNVAFSP The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: help The multiple alignment of the region surrounding the variant against various orthologous sequences. 
Human                         PRIAELMDKKLPSFGPYLEQRKKIIAENKIRLKEQNVAFSP

Mouse                         PRVAELMGQKLPSFGPYLEQRKKIIAASKIRQKDQNTACSP

Rat                           PHIAELMGQKLPSFGPYLERRKKILAASKIRENDQNRACSP

Pig                           PRIAELMGKKLPNFGPYLEQRKKIIAEEKMRLKEQNAAFPP

Bovine                        PCIAELVGKKLPSFGPYLEKCKKIIAEEKLRLKKENVTVLP

Zebrafish                     PHVSELIGKSLPSFGPYLQTKTQALAKYK-KDASGDVIMDT

Caenorhabditis elegans        LLQGQ---KKMPFFGKYRDEREKL---EAIKLSESNL--LD

Slime mold                    --------KGLPKFGKYLLERNRIDTEEKQNIDLQKVK-NP
Sequence annotation in neighborhood: help The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
  • Type: the type of sequence feature.
  • Positions: endpoints of the sequence feature.
  • Description: contains additional information about the feature.
TypePositionsDescription
Chain 4 – 1025 Dihydropyrimidine dehydrogenase [NADP(+)]
Modified residue 905 – 905 Phosphoserine
Alternative sequence 174 – 1025 Missing. In isoform 2.



Literature citations
Dihydropyrimidine dehydrogenase (DPD) deficiency: identification and expression of missense mutations C29R, R886H and R235W.
Vreken P.; van Kuilenburg A.B.P.; Meinsma R.; van Gennip A.H.;
Hum. Genet. 101:333-338(1997)
Cited for: VARIANTS DPYDD ARG-29; TRP-235 AND HIS-886; Identification of novel point mutations in the dihydropyrimidine dehydrogenase gene.
Vreken P.; van Kuilenburg A.B.P.; Meinsma R.; van Gennip A.H.;
J. Inherit. Metab. Dis. 20:335-338(1997)
Cited for: VARIANTS DPYDD ARG-29; TRP-235 AND HIS-886;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.