UniProtKB/Swiss-Prot P04279: Variant p.Ser79Thr

• Variant information
• Sequence information
• Literature citations
• All

Variant information

Variant position: 79 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Type of variant: LB/B The variants are classified into three categories: LP/P, LB/B and US.

• LP/P: likely pathogenic or pathogenic.
• LB/B: likely benign or benign.
• US: uncertain significance

Residue change: From Serine (S) to Threonine (T) at position 79 (S79T, p.Ser79Thr). Indicates the amino acid change of the variant. The one-letter and three-letter codes for amino acids used in UniProtKB/Swiss-Prot are those adopted by the commission on Biochemical Nomenclature of the IUPAC-IUB.
Physico-chemical properties: Change from small size and polar (S) to medium size and polar (T) The physico-chemical property of the reference and variant residues and the change implicated.
BLOSUM score: 1 The score within a Blosum matrix for the corresponding wild-type to variant amino acid change. The log-odds score measures the logarithm for the ratio of the likelihood of two amino acids appearing by chance. The Blosum62 substitution matrix is used. This substitution matrix contains scores for all possible exchanges of one amino acid with another:

• Lowest score: -4 (low probability of substitution).
• Highest score: 11 (high probability of substitution).

More information can be found on the following page
Variant description: Less common genetic variant. Any additional useful information about the variant.
Other resources: Links to websites of interest for the variant.

• Variant rs2301366 [ dbSNP | Ensembl ]

Sequence information

Variant position: 79 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 462 The length of the canonical sequence.
Location on the sequence: SKGSFSIQYTYHVDANDHDQ S RKSQQYDLNALHKTTKSQRH The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:

• Type: the type of sequence feature.
• Positions: endpoints of the sequence feature.
• Description: contains additional information about the feature.

Type	Positions	Description
Chain	24 – 462	Semenogelin-1
Peptide	68 – 159	Alpha-inhibin-92
Repeat	70 – 129	3-1
Region	70 – 439	Repeat-rich region

Literature citations

Evolution of the hominoid semenogelin genes, the major proteins of ejaculated semen.
Jensen-Seaman M.I.; Li W.-H.;
J. Mol. Evol. 57:261-270(2003)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS THR-79 AND LEU-372; Reduced polymorphism in the chimpanzee semen coagulating protein, semenogelin I.
Kingan S.B.; Tatar M.; Rand D.M.;
J. Mol. Evol. 57:159-169(2003)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 62-237 AND 241-449; VARIANT THR-79;