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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P40337: Variant p.Val170Phe

von Hippel-Lindau disease tumor suppressor
Gene: VHL
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Variant information Variant position: help 170
Type of variant: help LP/P [Disclaimer]
Residue change: help From Valine (V) to Phenylalanine (F) at position 170 (V170F, p.Val170Phe).
Physico-chemical properties: help Change from medium size and hydrophobic (V) to large size and aromatic (F)
BLOSUM score: help -1
Variant description: help In VHLD; type II.
Other resources: help


Sequence information Variant position: help 170
Protein sequence length: help 213
Location on the sequence: help NITLPVYTLKERCLQVVRSL V KPENYRRLDIVRSLYEDLED
Residue conservation: help 
Human                         N---ITLPVYTLKERCL-QVVRSLVK--PENYRR-----LDIVRSLYEDLED

                              N---ITLPVYTLKERCL-QVVRSLVK--PENYRR-----LD

Mouse                         N---ITLPVYTLKERCL-QVVRSLVK--PENYRR-----LD

Rat                           N---ITLPVYTLKERCL-QVVRSLVK--PENYRR-----LD

Caenorhabditis elegans        NHCVITMKVQSLRE----IAGRSFLRHNPTEVPNKI---KG

Drosophila                    SEVLIHFPMRSLRENCLWLVARWLIR--TSNAPRRIIHGYH
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 213 von Hippel-Lindau disease tumor suppressor



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.