Variant position: 852 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2813 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human QGKEYAPGETVKIGCNTCVC QDRKWNCTDHVCDATCSTIGM
Mouse QGAEYAPGDTVKIGCNTCVC RERKWNCTNHVCDATRSAIGM
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Nucleotide sequence of pre-pro-von Willebrand factor cDNA.
Bonthron D.; Orr E.C.; Mitsock L.M.; Ginsburg D.; Handin R.I.; Orkin S.H.;
Nucleic Acids Res. 14:7125-7128(1986)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1); VARIANTS ARG-852; ALA-1381 AND HIS-1472;
Structure of the gene for human von Willebrand factor.
Mancuso D.J.; Tuley E.A.; Westfield L.A.; Worrall N.K.; Shelton-Inloes B.B.; Sorace J.M.; Alevy Y.G.; Sadler J.E.;
J. Biol. Chem. 264:19514-19527(1989)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]; VARIANTS ILE-471; ARG-852; ALA-1381 AND HIS-1472;
Full-length von Willebrand factor (vWF) cDNA encodes a highly repetitive protein considerably larger than the mature vWF subunit.
Verweij C.L.; Diergaarde P.J.; Hart M.; Pannekoek H.;
EMBO J. 5:1839-1847(1986)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-1400 (ISOFORM 1); VARIANTS ARG-484; ARG-852 AND ALA-1381;
Amino acid sequence of human von Willebrand factor.
Titani K.; Kumar S.; Takio K.; Ericsson L.H.; Wade R.D.; Ashida K.; Walsh K.A.; Chopek M.W.; Sadler J.E.; Fujikawa K.;
Cited for: PROTEIN SEQUENCE OF 764-2813; VARIANTS ARG-852 AND ALA-1381;
Cloning and characterization of two cDNAs coding for human von Willebrand factor.
Sadler J.E.; Shelton-Inloes B.B.; Sorace J.M.; Harlan J.M.; Titani K.; Davie E.W.;
Proc. Natl. Acad. Sci. U.S.A. 82:6394-6398(1985)
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 744-873 AND 1289-2813 (ISOFORM 1); VARIANTS ALA-789; ARG-852 AND ALA-1381;
cDNA sequences for human von Willebrand factor reveal five types of repeated domains and five possible protein sequence polymorphisms.
Shelton-Inloes B.B.; Titani K.; Sadler J.E.;
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 781-1424 (ISOFORM 1); VARIANTS ARG-852 AND ALA-1381;
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