Variant position: 1584 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 2813 The length of the canonical sequence.
Location on the sequence:
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human RVREIRYQGGNRTNTGLALR YLSDHSFLVSQGDREQAPNLV
Mouse HVREIRYQGGNRTNTGQALQ YLSEHSFSPSQGDRVEAPNLV
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:
Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Two new candidate mutations in type IIA von Willebrand's disease (Arg834-->Gly, Gly846-->Arg) and one polymorphism (Tyr821-->Cys) in the A2 region of the von Willebrand factor.
Donner M.; Kristoffersson A.C.; Berntorp E.; Scheibel E.; Thorsen S.; Dahlback B.; Nilsson I.M.; Holmberg L.;
Eur. J. Haematol. 51:38-44(1993)
Cited for: VARIANTS VWD2 GLY-1597 AND ARG-1609; VARIANT CYS-1584;
The prevalence of the cysteine1584 variant of von Willebrand factor is increased in type 1 von Willebrand disease: co-segregation with increased susceptibility to ADAMTS13 proteolysis but not clinical phenotype.
Bowen D.J.; Collins P.W.; Lester W.; Cumming A.M.; Keeney S.; Grundy P.; Enayat S.M.; Bolton-Maggs P.H.; Keeling D.M.; Khair K.; Tait R.C.; Wilde J.T.; Pasi K.J.; Hill F.G.;
Br. J. Haematol. 128:830-836(2005)
Cited for: VARIANT CYS-1584;
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