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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Thr125Met

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 125
Type of variant: help US
Residue change: help From Threonine (T) to Methionine (M) at position 125 (T125M, p.Thr125Met).
Physico-chemical properties: help Change from medium size and polar (T) to medium size and hydrophobic (M)
BLOSUM score: help -1
Variant description: help In sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 125
Protein sequence length: help 393
Location on the sequence: help GSYGFRLGFLHSGTAKSVTC T YSPALNKMFCQLAKTCPVQL
Residue conservation: help 
Human                         GSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQL

                              GTYGFRLGFLHSGTAKSVTWTYSPLLNKLFCQLAKTCPVQL

Rhesus macaque                GSYGFRLGFLHSGTAKSVTCTYSPDLNKMFCQLAKTCPVQL

Mouse                         GNYGFHLGFLQSGTAKSVMCTYSPPLNKLFCQLAKTCPVQL

Rat                           GNYGFHLGFLQSGTAKSVMCTYSISLNKLFCQLAKTCPVQL

Pig                           GSYDFRLGFLHSGTAKSVTCTYSPALNKLFCQLAKTCPVQL

Bovine                        GNYGFRLGFLQSGTAKSVTCTYSPSLNKLFCQLAKTCPVQL

Rabbit                        GNYGFRLGFLHSGTAKSVTCTYSPCLNKLFCQLAKTCPVQL

Sheep                         GNYGFRLGFLHSGTAKSVTCTYSPSLNKLFCQLAKTCPVQL

Cat                           GAYGFHLGFLQSGTAKSVTCTYSPPLNKLFCQLAKTCPVQL

Chicken                       GDFDFRVGFVEAGTAKSVTCTYSPVLNKVYCRLAKPCPVQV

Xenopus laevis                GKYGLQLDFQQNGTAKSVTCTYSPELNKLFCQLAKTCPLLV

Zebrafish                     GDHGFRLRFPQSGTAKSVTCTYSPDLNKLFCQLAKTCPVQM
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Site 120 – 120 Interaction with DNA
Modified residue 120 – 120 N6-acetyllysine
Modified residue 120 – 120 N6-lactoyllysine
Modified residue 139 – 139 N6-lactoyllysine
Alternative sequence 1 – 132 Missing. In isoform 7, isoform 8 and isoform 9.
Beta strand 124 – 127



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.