Sequence information
Variant position: 138 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
TAKSVTCTYSPALNKMFCQL
A KTCPVQLWVDSTPPPGTRVR
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human TAKSVTCTYSPALNKMFCQLA KTCPVQLWVDSTPPPGTRVR
TAKSVTWTYSPLLNKLFCQLA KTCPVQLWVSSPPPPNTCVR
Rhesus macaque TAKSVTCTYSPDLNKMFCQLA KTCPVQLWVDSTPPPGSRVR
Mouse TAKSVMCTYSPPLNKLFCQLA KTCPVQLWVSATPPAGSRVR
Rat TAKSVMCTYSISLNKLFCQLA KTCPVQLWVTSTPPPGTRVR
Pig TAKSVTCTYSPALNKLFCQLA KTCPVQLWVSSPPPPGTRVR
Bovine TAKSVTCTYSPSLNKLFCQLA KTCPVQLWVDSPPPPGTRVR
Rabbit TAKSVTCTYSPCLNKLFCQLA KTCPVQLWVDSTPPPGTRVR
Sheep TAKSVTCTYSPSLNKLFCQLA KTCPVQLWVDSPPPPGTRVR
Cat TAKSVTCTYSPPLNKLFCQLA KTCPVQLWVRSPPPPGTCVR
Chicken TAKSVTCTYSPVLNKVYCRLA KPCPVQVRVGVAPPPGSSLR
Xenopus laevis TAKSVTCTYSPELNKLFCQLA KTCPLLVRVESPPPRGSILR
Zebrafish TAKSVTCTYSPDLNKLFCQLA KTCPVQMVVDVAPPQGSVVR
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 393
Cellular tumor antigen p53
DNA binding
102 – 292
Region
1 – 320
Interaction with CCAR2
Region
100 – 370
Interaction with HIPK1
Region
100 – 300
Required for interaction with ZNF385A
Region
113 – 236
Required for interaction with FBXO42
Region
116 – 292
Interaction with AXIN1
Site
120 – 120
Interaction with DNA
Modified residue
120 – 120
N6-acetyllysine; by KAT6A
Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.