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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Val147Gly

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 147
Type of variant: help US
Residue change: help From Valine (V) to Glycine (G) at position 147 (V147G, p.Val147Gly).
Physico-chemical properties: help Change from medium size and hydrophobic (V) to glycine (G)
BLOSUM score: help -3
Variant description: help In sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 147
Protein sequence length: help 393
Location on the sequence: help SPALNKMFCQLAKTCPVQLW V DSTPPPGTRVRAMAIYKQSQ
Residue conservation: help 
Human                         SPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQ

                              SPLLNKLFCQLAKTCPVQLWVSSPPPPNTCVRAMAIYKKSE

Rhesus macaque                SPDLNKMFCQLAKTCPVQLWVDSTPPPGSRVRAMAIYKQSQ

Mouse                         SPPLNKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQ

Rat                           SISLNKLFCQLAKTCPVQLWVTSTPPPGTRVRAMAIYKKSQ

Pig                           SPALNKLFCQLAKTCPVQLWVSSPPPPGTRVRAMAIYKKSE

Bovine                        SPSLNKLFCQLAKTCPVQLWVDSPPPPGTRVRAMAIYKKLE

Rabbit                        SPCLNKLFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKKSQ

Sheep                         SPSLNKLFCQLAKTCPVQLWVDSPPPPGTRVRAMAIYKKLE

Cat                           SPPLNKLFCQLAKTCPVQLWVRSPPPPGTCVRAMAIYKKSE

Chicken                       SPVLNKVYCRLAKPCPVQVRVGVAPPPGSSLRAVAVYKKSE

Xenopus laevis                SPELNKLFCQLAKTCPLLVRVESPPPRGSILRATAVYKKSE

Zebrafish                     SPDLNKLFCQLAKTCPVQMVVDVAPPQGSVVRATAIYKKSE
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Modified residue 139 – 139 N6-lactoyllysine



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.