Sequence information
Variant position: 151 The position of the amino-acid change on the UniProtKB canonical protein sequence.
Protein sequence length: 393 The length of the canonical sequence.
Location on the sequence:
NKMFCQLAKTCPVQLWVDST
P PPGTRVRAMAIYKQSQHMTE
The residue change on the sequence. Unless the variant is located at the beginning or at the end of the protein sequence, both residues upstream (20) and downstream (20) of the variant will be shown.
Residue conservation: The multiple alignment of the region surrounding the variant against various orthologous sequences.
Human NKMFCQLAKTCPVQLWVDSTP PPGTRVRAMAIYKQSQHMTE
NKLFCQLAKTCPVQLWVSSPP PPNTCVRAMAIYKKSEFVTE
Rhesus macaque NKMFCQLAKTCPVQLWVDSTP PPGSRVRAMAIYKQSQHMTE
Mouse NKLFCQLAKTCPVQLWVSATP PAGSRVRAMAIYKKSQHMTE
Rat NKLFCQLAKTCPVQLWVTSTP PPGTRVRAMAIYKKSQHMTE
Pig NKLFCQLAKTCPVQLWVSSPP PPGTRVRAMAIYKKSEYMTE
Bovine NKLFCQLAKTCPVQLWVDSPP PPGTRVRAMAIYKKLEHMTE
Rabbit NKLFCQLAKTCPVQLWVDSTP PPGTRVRAMAIYKKSQHMTE
Sheep NKLFCQLAKTCPVQLWVDSPP PPGTRVRAMAIYKKLEHMTE
Cat NKLFCQLAKTCPVQLWVRSPP PPGTCVRAMAIYKKSEFMTE
Chicken NKVYCRLAKPCPVQVRVGVAP PPGSSLRAVAVYKKSEHVAE
Xenopus laevis NKLFCQLAKTCPLLVRVESPP PRGSILRATAVYKKSEHVAE
Zebrafish NKLFCQLAKTCPVQMVVDVAP PQGSVVRATAIYKKSEHVAE
Sequence annotation in neighborhood: The regions or sites of interest surrounding the variant. In general the features listed are posttranslational modifications, binding sites, enzyme active sites, local secondary structure or other characteristics reported in the cited references. The "Sequence annotation in neighborhood" lines have a fixed format:Type: the type of sequence feature. Positions: endpoints of the sequence feature. Description: contains additional information about the feature.
Type Positions Description
Chain
1 – 393
Cellular tumor antigen p53
DNA binding
102 – 292
Region
1 – 320
Interaction with CCAR2
Region
100 – 370
Interaction with HIPK1
Region
100 – 300
Required for interaction with ZNF385A
Region
113 – 236
Required for interaction with FBXO42
Region
116 – 292
Interaction with AXIN1
Literature citations
p53 alterations in human squamous cell carcinomas and carcinoma cell lines.
Caamano J.; Zhang S.Y.; Rosvold E.A.; Bauer B.; Klein-Szanto A.J.P.;
Am. J. Pathol. 142:1131-1139(1993)
Cited for: VARIANTS SPORADIC CANCERS SER-151; PRO-156; LYS-174; ARG-194; CYS-220; GLN-248; LEU-248 AND HIS-273;
Disclaimer:
Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.