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UniProtKB/Swiss-Prot variant pages

UniProtKB/Swiss-Prot P04637: Variant p.Pro153Thr

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 153
Type of variant: help US
Residue change: help From Proline (P) to Threonine (T) at position 153 (P153T, p.Pro153Thr).
Physico-chemical properties: help Change from medium size and hydrophobic (P) to medium size and polar (T)
BLOSUM score: help -1
Variant description: help In sporadic cancers; somatic mutation.


Sequence information Variant position: help 153
Protein sequence length: help 393
Location on the sequence: help MFCQLAKTCPVQLWVDSTPP P GTRVRAMAIYKQSQHMTEVV
Residue conservation: help 
Human                         MFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVV

                              LFCQLAKTCPVQLWVSSPPPPNTCVRAMAIYKKSEFVTEVV

Rhesus macaque                MFCQLAKTCPVQLWVDSTPPPGSRVRAMAIYKQSQHMTEVV

Mouse                         LFCQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVV

Rat                           LFCQLAKTCPVQLWVTSTPPPGTRVRAMAIYKKSQHMTEVV

Pig                           LFCQLAKTCPVQLWVSSPPPPGTRVRAMAIYKKSEYMTEVV

Bovine                        LFCQLAKTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMTEVV

Rabbit                        LFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMTEVV

Sheep                         LFCQLAKTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMTEVV

Cat                           LFCQLAKTCPVQLWVRSPPPPGTCVRAMAIYKKSEFMTEVV

Chicken                       VYCRLAKPCPVQVRVGVAPPPGSSLRAVAVYKKSEHVAEVV

Xenopus laevis                LFCQLAKTCPLLVRVESPPPRGSILRATAVYKKSEHVAEVV

Zebrafish                     LFCQLAKTCPVQMVVDVAPPQGSVVRATAIYKKSEHVAEVV
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Modified residue 139 – 139 N6-lactoyllysine



Literature citations
No reference for the current variant in UniProtKB/Swiss-Prot.
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.