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UniProtKB/Swiss-Prot P04637: Variant p.Val157Phe

Cellular tumor antigen p53
Gene: TP53
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Variant information Variant position: help 157
Type of variant: help US
Residue change: help From Valine (V) to Phenylalanine (F) at position 157 (V157F, p.Val157Phe).
Physico-chemical properties: help Change from medium size and hydrophobic (V) to large size and aromatic (F)
BLOSUM score: help -1
Variant description: help In sporadic cancers; somatic mutation.
Other resources: help


Sequence information Variant position: help 157
Protein sequence length: help 393
Location on the sequence: help LAKTCPVQLWVDSTPPPGTR V RAMAIYKQSQHMTEVVRRCP
Residue conservation: help 
Human                         LAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCP

                              LAKTCPVQLWVSSPPPPNTCVRAMAIYKKSEFVTEVVRRCP

Rhesus macaque                LAKTCPVQLWVDSTPPPGSRVRAMAIYKQSQHMTEVVRRCP

Mouse                         LAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRRCP

Rat                           LAKTCPVQLWVTSTPPPGTRVRAMAIYKKSQHMTEVVRRCP

Pig                           LAKTCPVQLWVSSPPPPGTRVRAMAIYKKSEYMTEVVRRCP

Bovine                        LAKTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMTEVVRRCP

Rabbit                        LAKTCPVQLWVDSTPPPGTRVRAMAIYKKSQHMTEVVRRCP

Sheep                         LAKTCPVQLWVDSPPPPGTRVRAMAIYKKLEHMTEVVRRSP

Cat                           LAKTCPVQLWVRSPPPPGTCVRAMAIYKKSEFMTEVVRRCP

Chicken                       LAKPCPVQVRVGVAPPPGSSLRAVAVYKKSEHVAEVVRRCP

Xenopus laevis                LAKTCPLLVRVESPPPRGSILRATAVYKKSEHVAEVVKRCP

Zebrafish                     LAKTCPVQMVVDVAPPQGSVVRATAIYKKSEHVAEVVRRCP
Sequence annotation in neighborhood: help
TypePositionsDescription
Chain 1 – 393 Cellular tumor antigen p53
DNA binding 102 – 292
Region 1 – 320 Interaction with CCAR2
Region 100 – 370 Interaction with HIPK1
Region 100 – 300 Required for interaction with ZNF385A
Region 113 – 236 Required for interaction with FBXO42
Region 116 – 292 Interaction with AXIN1
Binding site 176 – 176
Modified residue 139 – 139 N6-lactoyllysine
Beta strand 156 – 165



Literature citations
The consensus coding sequences of human breast and colorectal cancers.
Sjoeblom T.; Jones S.; Wood L.D.; Parsons D.W.; Lin J.; Barber T.D.; Mandelker D.; Leary R.J.; Ptak J.; Silliman N.; Szabo S.; Buckhaults P.; Farrell C.; Meeh P.; Markowitz S.D.; Willis J.; Dawson D.; Willson J.K.V.; Gazdar A.F.; Hartigan J.; Wu L.; Liu C.; Parmigiani G.; Park B.H.; Bachman K.E.; Papadopoulos N.; Vogelstein B.; Kinzler K.W.; Velculescu V.E.;
Science 314:268-274(2006)
Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-134; PHE-157; CYS-163; HIS-175; ARG-177; ARG-193; PRO-213; PHE-241; PHE-242; GLN-248; TRP-248; SER-249; TRP-267; LYS-271; CYS-273; HIS-273; LEU-273; SER-278; ILE-280 AND HIS-281;
Disclaimer: Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. They are not in any way intended to be used as a substitute for professional medical advice, diagnostic, treatment or care.